New research indicates that patients who stop using popular slimming jabs like semaglutide or tirzepatide may regain shed pounds much more quickly than those who end conventional diet and exercise plans.
Findings released in a prominent medical journal shows that while overweight individuals frequently drop substantial amounts of their total mass while undergoing treatment, the mass comes back at an average rate of 0.8 kg per month after stopping.
"Users using such medications need to be informed of the risk of rapid rebound weight gain when the medication ends," warns lead investigator Dr. Susan Jebb.
This pace of recovery suggests a return to pre-treatment mass in about one and a half years.
Comparing Treatments
The study, which looked at 37 of trials involving over 9,000 of participants, compared the effects of these new drugs with conventional dieting.
Researchers note that individuals who lose weight through diet and exercise usually see a slower creep back—perhaps 100 grams monthly—after stopping.
Explaining the Fast Rebound
Experts suggest the way of the drugs is key to understanding the amplified rebound.
These medications imitate a body's own chemical called glucagon-like peptide-1, which controls feelings of fullness.
"Sustained high doses of GLP-1 levels far above than normal could lead to the system to generate a reduced amount of its own natural hormone, and may also lessen responsiveness to its effects," said Dr. Adam Collins, a dietetics specialist.
"Discontinuation of this medication results in appetite is no longer kept in check, making excessive eating a significant risk."
A Lifelong Condition?
The NHS advise the injections for individuals with weight-linked health risks, accompanied by prescribed lifestyle changes.
Professionals say that, considering the significant potential of weight regain, the therapy might need to be life-long.
This perspective is supported by pharmaceutical companies, who note that the results "emphasize the chronic character of excess weight," akin to managing diseases like diabetes.
User Testimonies
Users who have come off the medication report a sudden resurgence of appetite.
"I experienced a trigger that goes on and you're instantly extremely hungry," said a patient.
The struggle is compounded if individuals have not adopted sustainable dietary or behavioural changes during treatment.
Widespread Interest
Recent estimates indicate that millions of adults in the UK have tried these injections in the last 12 months, with interest remaining high.
- Adoption is greater among females than men.
- The middle-aged age group shows the greatest usage rates.
- Many obtain the drugs through private prescriptions rather than public health services.
Ultimately, clinicians caution that while these medications are effective agents for weight loss, they are not a magic fix and maintained weight loss relies on integrated behavioural changes.
